The whole Exercise Biology Group wish all of you a "Happy New Year" and we celebrate this with our first paper in the year 2022. Congratulation to our PhD Fakhreddin Yaghoob Nezhad who has worked on the Hippo signal transduction network during his PhD thesis and wrote our current paper.
The Hippo signal transduction network regulates transcription through Yap/Taz-Tead1-4 in many tissues including skeletal muscle. Whilst transgenic mice have been generated for many Hippo genes, the resultant skeletal muscle phenotypes were not always characterized. In our current paper, we aimed to phenotype the hindlimb muscles of Hippo gene-mutated Lats1−/−, Mst2−/−, Vgll3−/−, and Vgll4+/− mice. The paper was recently published in Transgenic Research. If you are intereseted in the whole paper, please follow this link.
Citation information:
Nezhad, Fakhreddin Yaghoob; Riermeier, Annett; Schönfelder, Martin; Becker, Lore; de Angelis, Martin Hrabĕ; Wackerhage, Henning. Skeletal muscle phenotyping of Hippo gene-mutated mice reveals that Lats1 deletion increases the percentage of type I muscle fibers. Transgenic Res (2022).