New Paper - Common and Distinctive Functions of the Hippo Effectors Taz and Yap in Skeletal Muscle Stem Cell Function

Sport- und Gesundheitswissenschaften, TUSPFSP-newscat-exercisebiology |

We are very happy to present you our latest publication in STEM CELLS this year, dealing with common and distinctive functions of the Hippo effectors Taz and Yap in skeletal muscle stem cell. The Hippo pathway downstream effectors Yap and Taz play key roles in cell proliferation and regeneration, regulating gene expression especially via Tead transcription factors. In this work we investigated their role in skeletal muscle stem cells and analysed Taz in vivo and ex vivo in comparison to Yap. Finally, TAZ operates through Tead4 to enhance myogenic differentiation. In summary, Taz and Yap have overlapping functions in promoting myoblast proliferation but Taz then switches to enhance myogenic differentiation. For more information we will find the whole paper here. If you have the rights, you will get also the PDF full version of the article.