We want to invite you to the upcoming Molecular Exercise Physiology Meeting at 21st of July 2022 16.00-18.40 h (Munich time, UTC+1). You can register here for the Zoom-Meeting.
Nearly 100 years ago, Otto Warburg discovered that tumours take up more glucose and increase glycolytic flux in the presence of oxygen. Today we know that a key function of this metabolic reprogramming is to channel energy metabolites into anabolism, i.e., DNA, RNA, and protein synthesis. In this Zoom meeting, we ask the question whether a hypertrophying muscle similarly reprograms its metabolism and whether such reprogramming can explain why the stimulation of muscle hypertrophy typically improves glucose homeostasis and reduces body fat. We will also explore the implications for the treatment of type 1 & 2 diabetes mellitus, obesity, and hypogonadism.
Programme
Time (UTC+1) | Speaker, title |
16.00-16.10h | Martin Hrabê de Angelis (moderator): Welcome, announcements, brief introduction of programme and speakers |
16.10-16.30h | Henning Wackerhage: Connecting the dots: Otto Warburg, muscle hypertrophy, diabetes, obesity & hypogonadism |
16.30-17.10h | Ralph DeBerardinis: Keynote presentation: Metabolic heterogeneity and liabilities in cancer |
17.10-17.30h | Yasuhiro Izumiya: Muscle hypertrophy results in weight and fat loss, and glucose normalisation in mice on a high fat, high sugar diet |
17.30-17.50h | Ivan Vechetti: The role of NADPH in the regulation of skeletal muscle growth |
17.50-18.10h | Frits van Heijster: Imaging cancer and muscle metabolism in vivo |
18.10-18.30h | Anna Thalacker-Mercer: Metabolic reprogramming for skeletal muscle nutrient requirements |
18.30-18.40h | Closing comments & discussion |
*Each time slot should leave at least 5 min for questions. 16 h Munich (UTC+1) is 9 h Texas time. Times are strict. Organisation: Martin Schönfelder & Philipp Baumert.
Speaker information
Dr. Martin Hrabê de Angelis is the Research Director at the HelmholtzZentrum Munich and Chair of Experimental Genetics at the Technical University of Munich. He is Speaker and Member of the Board of the German Center for Diabetes Research (DZD). His research is on genetics and epigenetics with a focus on metabolism and diabetes.
Prof. Dr. Henning Wackerhage leads the Technical University of Munich Exercise Biology group. The group aims to discover mechanisms by which exercise improves our performance, fitness, and health.
Dr. Ralph DeBerardinis is a Professor in the Children’s Research Institute at UT Southwestern and Investigator in the Howard Hughes Medical Institute. His lab studies the role of metabolic perturbations in human cancer and other diseases.
Prof. Dr. Yasuhiro Izumiya, MD, is at the Osaka City University and the lead author of the key Cell Metabolism paper that demonstrated the anti-diabetes and anti-obesity effects of muscle hypertrophy. Current projects in his lab are to identify and characterize skeletal muscle-derived cardio-renal protective factors.
Dr. Ivan Vechetti is an assistant Professor at the University of Nebraska-Lincoln. His laboratory focuses on skeletal muscle mass, microRNAs, extracellular vesicles, and metabolism.
Dr. Frits van Heijster is a postdoctoral researcher in Prof. Dr. Fanz Schilling’s Biomedical MR group, focusing on detecting changes in metabolism in preclinical models of cancer and muscle hypertrophy, using different imaging techniques (MR/PET).
Dr. Anna Thalacker-Mercer is an assistant Professor in the Department of Cell, Developmental and Integrative Biology and Associated Director of the Center for Exercise Medicine at the University of Alabama at Birmingham, USA. Her laboratory focuses primarily on nutrient and metabolic determinants of skeletal muscle regeneration, composition, and homeostasis.
Background reading
DeBerardinis, R.J., and Chandel, N.S. (2016). Fundamentals of cancer metabolism. Sci Adv 2, e1600200. 10.1126/sciadv.1600200.
Izumiya, Y., Hopkins, T., Morris, C., Sato, K., Zeng, L., Viereck, J., Hamilton, J.A., Ouchi, N., LeBrasseur, N.K., and Walsh, K. (2008). Fast/Glycolytic muscle fiber growth reduces fat mass and improves metabolic parameters in obese mice. Cell metabolism 7, 159-172. 10.1016/j.cmet.2007.11.003.
Wackerhage, H., Vechetti, I.J., Baumert, P., Gehlert, S., Becker, L., Jaspers, R.T., and de Angelis, M.H. (2022). Does a Hypertrophying Muscle Fibre Reprogramme its Metabolism Similar to a Cancer Cell? Sports medicine. 10.1007/s40279-022-01676-1.